1338807-48-9

Upstream product

• 1338807-53-6 (R)-N-benzyl-N-(α-methylbenzyl)formamide 
• 1338807-45-6 (1R,2S)-{N-benzyl-N-[(1R)-1-phenylethyl]}-2-vinylcyclopropanamine 
• 38235-77-7 (R)-N-benzyl-1-phenylethylamine 

Downstream Products

• 1338807-54-7 tert-butyl [(1R,2S)-2-(2-hydroxyethyl)cyclopropyl][(1R)-1-phenylethyl]carbamate 
• 171550-09-7 tert-butyl [(1R,2S)-2-(2-hydroxyethyl)cyclopropyl]carbamate 
• 308266-57-1 (1S,2R)-2-(t-buthoxycarbonyl)amino-1-(carboxymethyl)cyclopropane 

Relevant academic research and scientific papers

Stereoselective preparation of β,γ-methano-GABA derivatives

The Kulinkovich-de Meijere reaction between an unsaturated Grignard reagent and a chiral amide takes place with a high trans stereoselectivity and provides a convenient access to non-racemic trans cyclopropylamines. These compounds are transformed in four steps into the corresponding N-protected β,γ-methano-GABA derivatives, which are obtained for the first time in enantiomerically pure form. The corresponding transformations of the cis cyclopropylamine adducts are also described.