133891-52-8Relevant academic research and scientific papers
ANTAGONISTS OF SNS SODIUM CHANNELS
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Page/Page column 35-36, (2010/11/25)
Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents, formula (I): R1 represents: (a) -L-A or -L' -A'
7-Azetidinylquinolones as antibacterial agents. Synthesis and structure- activity relationships
Frigola,Pares,Corbera,Vano,Merce,Torrens,Mas,Valenti
, p. 801 - 810 (2007/10/02)
A series of novel antibacterial quinolones and naphthyridones has been prepared which contain 7-azetidinyl substituents in place of the usual piperazine or aminopyrrolidine groups. These azetidinyl derivatives were evaluated for in vitro activity by deter
Quantitative structure-activity relationships of antibacterial agents, 7-heterocyclic amine substituted 1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acids
Okada,Ezumi,Yamakawa,Sato,Tsuji,Tsushima,Motokawa,Komatsu
, p. 126 - 131 (2007/10/02)
Quantitative structure-activity relationships (QSAR) of various 7-(3-substituted-azetidin-1-yl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro -4-oxoquinoline-3-carboxylic acids, 14-25, were studied to clarify the structural requirements for 3-substituted azetidi
Substituted 1-diphenylmethyl azetidines
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, (2008/06/13)
New azetidines, characterized in that they correspond to the general formula (I) STR1 in which R3 represents an amino radical, an alkylamino radical, a dialkylamino radical, a cycloalkylamino radical, an acylamino radical, an alkylacylamino radical, an aminomethyl radical, an alkylaminomethyl radical, an acylaminomethyl radical or an alkylacylaminomethyl radical, in which radicals each acyl fragment may be substituted with one or more halogen, especially fluorine, atoms; and R1, R2, R4, R5 and R6 represent a hydrogen atom or a lower alkyl radical, with the proviso that at least one of them represents a lower alkyl radical, and also their salts.
