133902-82-6Relevant academic research and scientific papers
GPR139 RECEPTOR MODULATORS
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Page/Page column 141; 142, (2021/06/26)
Compounds are provided that modulate the GPR139 receptor, compositions containing the same, and to methods of their preparation and use for treatment of a malcondition wherein modulation of the GPR139 receptor is medically indicated or beneficial. Such compounds have the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R4, R5, R9, R10, Q6, Q7, and Q12 are as defined herein.
A Convenient Synthesis of 1-Aryl-3-methyl-1,2,4-triazolin-5-ones From the Reaction Between Acetone Arylhydrazones and Acetyl Isocyanate
Ray, Partha S.,Hank, Richard F.
, p. 2017 - 2020 (2007/10/02)
The reaction of acetone arylhydrazones with acetyl isocyanate gave the corresponding 4-acetyl-1-aryl-3,3-dimethyl-1,2,4-triazolidin-5-ones which eliminated acetone upon hydrolysis to give 1-aryl-3-methyl-1,2,4-triazolin-5-ones.The above transformation can be achieved in one pot by a simple solvent swap.
