133950-83-1Relevant academic research and scientific papers
α-Amidoaldehydes as Substrates in Rhodium-Catalyzed Intermolecular Alkyne Hydroacylation: The Synthesis of α-Amidoketones
O'Brien, Sean C.,Pal, Ritashree,Willis, Michael C.
, p. 11710 - 11714 (2020/08/03)
We show that readily available α-amidoaldehydes are effective substrates for intermolecular Rh-catalyzed alkyne hydroacylation reactions. The catalyst [Rh(dppe)(C6H5F)][BArF4] provides good reactivity, and allows a broad range of aldehydes and alkynes to be used as substrates, delivering α-amidoketone products. High yields and high levels of regioselectivity are achieved. The use of α-amidoaldehydes as substrates establishes that 1,4-dicarbonyl motifs can be used as controlling groups in Rh-catalyzed hydroacylation reactions.
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
Tremblay, Martin R.,Nevalainen, Marta,Nair, Somarajan J.,Porter, James R.,Castro, Alfredo C.,Behnke, Mark L.,Yu, Lin-Chen,Hagel, Margit,White, Kerry,Faia, Kerrie,Grenier, Louis,Campbell, Matthew J.,Cushing, Jill,Woodward, Caroline N.,Hoyt, Jennifer,Foley, Michael A.,Read, Margaret A.,Sydor, Jens R.,Tong, Jeffrey K.,Palombella, Vito J.,McGovern, Karen,Adams, Julian
supporting information; experimental part, p. 6646 - 6649 (2009/11/30)
Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed rearran
CYCLOPAMINE ANALOGUES AND METHODS OF USE THEREOF
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Page/Page column 61-62, (2010/10/20)
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgeho
