1339570-02-3

Basic information

• Product Name: 2-hydroxy-N-methoxy-N,3-dimethylbenzamide
• Synonyms: 2-hydroxy-N-methoxy-N,3-dimethylbenzamide
• CAS NO: 1339570-02-3
• Molecular Weight: 195.218
• Mol File: 1339570-02-3.mol

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-N-methoxy-N,3-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-methoxy-N,3-dimethylbenzamide(1339570-02-3)
• EPA Substance Registry System: 2-hydroxy-N-methoxy-N,3-dimethylbenzamide(1339570-02-3)

Safety Data

• Hazardous Substances Data: 1339570-02-3(Hazardous Substances Data)

Upstream product

• 135754-82-4 3-methyl-N-methoxy-N-methylbenzamide 
• 1711-06-4 3-Methylbenzoyl chloride 

Relevant articles and documents

C?H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes

The catalytic generation of hypervalent iodine(III) reagents by anodic electrooxidation was orchestrated towards an unprecedented electrocatalytic C?H oxygenation of weakly coordinating aromatic amides and ketones. Thus, catalytic quantities of iodoarenes in concert with catalytic amounts of ruthenium(II) complexes set the stage for versatile C?H activations with ample scope and high functional group tolerance. Detailed mechanistic studies by experiment and computation substantiate the role of the iodoarene as the electrochemically relevant species towards C?H oxygenations with electricity as a sustainable oxidant and molecular hydrogen as the sole by-product. para-Selective C?H oxygenations likewise proved viable in the absence of directing groups.

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Ruthenium-catalyzed C-h oxygenation on aryl Weinreb amides

Versatile ruthenium catalysts enabled unprecedented C-H bond oxygenations of aryl Weinreb amides with ample scope under exceedingly mild reaction conditions, thereby also giving access to valuable ortho-hydroxylated aldehydes. Mechanistic studies provided strong support for a kinetically relevant C-H bond activation.