133958-07-3Relevant academic research and scientific papers
Synthesis of 2,3-Disubstituted Thiophenes from 1,3-Dimetallated Acetylenes and Non-Enolizable Thiocarbonyl Compounds
Jong, R.L.P. de,Brandsma, L.
, p. 3427 - 3431 (2007/10/02)
Reaction of 1,3-dimetallated acetylenes KCC-CH(K)R (R = alkyl, O-alkyl, S-alkyl, aryl, N(alkyl)2) with non-enolizable thiocarbonyl compounds XCSSCH3 (X = aryl, heteroaryl, t-Bu, CH3O, t-BuO, CH3S, N(alkyl)2) gives 2,3-disubstituted thiophenes (6) having X in the 2-position and R in the 3-position.
