13396-94-6

Basic information

• Product Name: 1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine
• Synonyms: 5-(2-Aminopropyl)-2,3-dihydro-1H-indene; 5-Nprop-di hcl; Indanylaminopropane (IAP)
• CAS NO: 13396-94-6
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.2701
• Mol File: 13396-94-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 286 °C at 760 mmHg
• Flash Point: 118.8 °C
• Density: 1.019 g/cm³
• CAS DataBase Reference: 1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine(13396-94-6)
• EPA Substance Registry System: 1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine(13396-94-6)

Safety Data

• Hazardous Substances Data: 13396-94-6(Hazardous Substances Data)

Usage

General Description

1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine is a complex organic compound that consists of a propylamine chain attached to the 5-position of a dihydroindenyl group. This chemical structure classifies it as part of the amine family, which consists of molecules that contain a basic nitrogen atom with a lone pair of electrons. Amine compounds, including this one, are known for their reactive properties particularly towards acids. Like many other amines, 1-(2,3-dihydro-1H-inden-5-yl)propan-2-amine primarily finds use in chemical research and industry, where it may contribute to the formation of polymers, dyes or pharmaceuticals. However, specific applications of this compound are not widely discussed in available literature.

Upstream product

• 30084-91-4 indan-5-carbaldehyde 
• 496-11-7 INDANE 

Relevant articles and documents

Synthesis and Pharmacological Examination of Benzofuran, Indan, and Tetralin Analogues of 3,4-(Methylenedioxy)amphetamine

Benzofuran, indan and tetrahydronaphthalene analogs of 3,4-(methylenedioxy)amphetamine (MDA) were prepared in order to examine the role of the dioxole ring oxygen atoms of MDA in interacting with the serotonin and catecholamine uptake carriers.The series of compounds was evaluated for discriminative stimulus effects in rats trained to discriminate saline from the training drugs (S)-(+)-MBDB (1c), MMAI (3), and (S)-(+)-amphetamine and for the ability to inhibit the uptake of 3H>serotonin, 3H>dopamine, and 3H>norepinephrine into crude synaptosome preparations.Behaviorally, the benzofuran and indan analogs 4-6 produced similar discriminative cues, whereas the tetralin derivative 7 did not fully substitute for the training drugs.The results in the in vitro pharmacology studies indicate that selectivity for 5-HT versus catecholamine uptake carriers may be modulated by the position and orientation of ring oxygen atoms.However, the nonoxygenated isostere 6 possessed high potency at all uptake sites examined.Enlargement of the saturated ring by one methylene unit to give the tetralin derivative resulted in a large (3-4-fold) reduction in activity at catecholamine sites.