1339650-77-9

Basic information

• Product Name: 4-chloro-2-mercaptobenzonitrile
• Synonyms: 4-chloro-2-mercaptobenzonitrile
• CAS NO: 1339650-77-9
• Molecular Weight: 169.634
• Mol File: 1339650-77-9.mol

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-mercaptobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-mercaptobenzonitrile(1339650-77-9)
• EPA Substance Registry System: 4-chloro-2-mercaptobenzonitrile(1339650-77-9)

Safety Data

• Hazardous Substances Data: 1339650-77-9(Hazardous Substances Data)

Upstream product

• 934180-42-4 2-(benzylthio)-4-chlorobenzamide 
• 131002-01-2 2-bromo-4-chlorobenzamide 
• 57381-49-4 2-bromo-4-chloro-benzonitrile 
• 57381-51-8 4-chloro-2-fluorobenzonitrile 

Downstream Products

• 935433-81-1 2-((2-amino-4-carboxyphenyl)thio)-4-chlorobenzoic acid 

Relevant articles and documents

NOVEL GALACTOSIDE INHIBITOR OF GALECTINS

The present invention relates to a D-galactopyranose compound of formula (1) wherein the pyranose ring is α-D-galactopyranose, and these compounds are high affinity galectin-1 and/or galectin 3 inhibitors for use in treatment of inflammation; fibrosis; scarring; keloid formation; aberrant scar formation; surgical adhesions; septic shock; cancer; metastasising cancers; autoimmune diseases, metabolic disorders; heart disease; heart failure; pathological angiogenesis; eye diseases; atherosclerosis; metabolic diseases; diabetes type I; diabetes type II; insulin resistance; Diastolic heart failure; asthma; liver disorders.

SUBSTITUTED PYRROLIDINE AMIDES IV

The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

NOVEL GALACTOSIDE INHIBITOR OF GALECTINS

The present invention relates to a compound of the general formula (I) wherein the pyranose ring is a-D-galactopyranose, R1 is selected from the group consisting of (II) wherein the asterix 1 * indicates the carbon atom of the heteroaromatic ring that is covalently attached to the triazole group of formula (I). The compound of formula (I) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-1 to a ligand in a mammal, such as a human.

Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives

Since pyrithiobac (PTB) is a successful commercial herbicide with very low toxicity against mammals, it is worth exploring its derivatives for an extensive study. Herein, a total of 35 novel compounds were chemically synthesized and single crystal of 6–6

HEPATITIS B CORE PROTEIN MODULATORS

The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY

The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Synthesis of substituted benzothieno[3,2-c]isoquinolin-5(6H)-ones and their sulfinyl and sulfonyl derivatives

An approach to the synthesis of substituted benzothieno[3,2-c]isoquinolin-5(6H)-ones with good yields was suggested, which consists of the condensation of substituted 2-mercaptobenzo-nitriles with methyl 2-(chloromethyl)benzoate and subsequent treatment o

About the reaction of aryl fluorides with sodium sulfide: Investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via SNAr displacement of fluorine

In this report we describe a simple synthesis of mercaptobenzonitriles from the reaction of fluorobenzonitriles with Na2S in DMF at room temperature and following direct treatment with Zn/HCl. Significantly, 2- and 4-fluorobenzonitriles substituted with chlorine or bromine, but not iodine, undergo selective substitution of fluorine at room temperature to yield synthetically useful halo-substituted mercaptobenzonitriles.