133978-98-0

Basic information

• Product Name: N'-[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester
• CAS NO: 133978-98-0
• Molecular Weight: 226.323
• Mol File: 133978-98-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N'-[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N'-[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester(133978-98-0)
• EPA Substance Registry System: N'-[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester(133978-98-0)

Safety Data

• Hazardous Substances Data: 133978-98-0(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 97215-68-4 C₈H₈N₂OS₂ 
• 74-88-4 methyl iodide 
• 5397-03-5 hydrazinecarbodithioic acid methyl ester 

Downstream Products

• 1344115-34-9 N-hydroxy-4-{[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-carbonothioyl}-piperazine-1-carboxamide 
• 1279049-55-6 C₁₅H₁₄N₄O₃S 
• 1237537-68-6 C₁₃H₁₇N₅O₃S 
• 14938-70-6 2-hydroxybenzaldehyde 4-phenylthiosemicarbazone 
• 14121-95-0 4-(4-chlorophenyl)-1-[(2-hydroxyphenyl)methylidene]-3-thiosemicarbazide 

Relevant articles and documents

Synthesis, characterization, X-ray crystallography, and antimicrobial activities of Ni(II) and Cu(II) complexes with a salicylaldehyde-based thiosemicarbazone ligand

A new salicylaldehyde-based ONS tridentate salicylaldehyde-N(4)- diethylthiosemicarbazone (H2SANEt2) has been synthesized and characterized by elemental analyses mass, IR, and 1H NMR spectral parameters. The coordination m

Methyl-2-arylidene hydrazinecarbodithioates: Synthesis and biological activity

Methyl-2-arylidene hydrazine-carbodithioate has not been of particular interest to researchers even though its metal complexes are extensively reported on due to their biological activity. This study examined the cytostatic and antiviral activity of twelve methyl-2-arylidene hydrazinecarbodithioates reported by many researchers as intermediates for the synthesis of thiosemicarbazides and the preparation of their metal complexes. Compounds IIc, IIi, and IIl with tridentate ligand features were found to have the lowest IC50 value (6.5 μM, ≈ 1 μM, and 0.8 μM, respectively) against HL60 human promyelocytic leukemia cells. They were also most inhibitory to human embryonic lung (HEL) fibroblast proliferation (5.3 μM, 17 μM, and 2.6 μM). Compound IIc and IIl show antiviral activity against wild-type herpes simplex virus (HSV), varicella zoster virus (VZV), and acyclovirresistant HSV; however, these activities were observed at concentrations at which the compounds also markedly inhibit HL60 and HEL cell proliferation.

Synthesis, antimicrobial and anticancer activity of new thiosemicarbazone derivatives

Thiosemicarbazones of p-aminobenzoic acid (PABA) were synthesized and tested for their antimicrobial and anticancer activity. Hydroxamate derivatives 4a-4l were found to have better antimicrobial and anticancer activity than their acid counterpart. Compound 4d was found to have good antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Vibrio cholerae, and Bacillus subtilis with IC50 value of about 1 aμM. Compound 4f showed potent antifungal activity against Candida albicans (IC50a=a1.29 aμM) and compound 4h showed potent anticancer activity (IC50a=a0.07 aμM). Hydroxamate derivatives 4a-4l were found to show better antimicrobial and anticancer activity in compariosn with their acid counterparts 3a-3l. Copyright