13398-53-3

Upstream product

• 2683-72-9 (S)-2-amino-2-phenyl-propionic acid ethyl ester 
• 393536-53-3 (R_S,1S)-2-methylpropane-2-sulfinic acid (2-benzyloxy-1-methyl-1-phenylethyl)amide 
• 13398-26-0 (S)-2-methyl-2-phenylglycine 
• 393536-64-6 (R_S,1S)-2-methylpropane-2-sulfinic acid [2-(tert-butyldimethylsilanyloxy)-1-methyl-1-phenylethyl]amide 
• 222733-19-9 (S,S)-<2-(tert-butyldimethylsilyloxy)-1-phenylethyl>-(2-methoxy-1-methyl-1-phenylethyl)-amine 
• 222733-14-4 (S,S)-2-(2-methoxy-1-methyl-1-phenylethylamino)-2-phenylethanol 

Downstream Products

• 1439557-46-6 C₃₇H₄₀N₆O₄S 

Relevant academic research and scientific papers

IMIDAZOPYRIDINE COMPOUNDS

[Problem] A pharmaceutical composition for treating or preventing various cardiovascular diseases, which have sGC activities based on improvement of cGMP signals, is provided. [Means for Solution] It was found that imidazo[1,2-a]pyridine compounds having

Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines

tert-Butanesulfinyl aldimines and ketimines bearing an α-benzyloxy or α-silyloxy substituent serve as precursors in the synthesis of protected 1,2-amino alcohols in high yields and diastereoselectivities. General protocols are described for the addition of unbranched alkyl, branched alkyl, and aryl organometallic reagents to N-sulfinyl aldimines 1 and 2 and ketimines 5 and 6. Furthermore, the selective N- or O-deprotection of sulfinamide products 3, 4, 7, and 8 is described, enabling further synthetic transformations of the reaction products.

Highly diastereoselective addition of Grignard reagents to aliphatic, enolizable N-alkylketimines and 2,2-disubstituted 1,3-oxazolidines. Asymmetric synthesis of the antidepressant cericlamine

Grignard reagents were added to 2,2-disubstituted 1,3-oxazolidines and enolizable ketimines prepared from hydroxyacetone and phenylglycinol derivatives, with high to excellent diastereoselectivity, to yield 2,2- disubstituted 1,2-amino alcohol derivatives. Lewis acids had considerable influence on the yield and diastereoselectivity of the addition. This method was applied to the first asymmetric synthesis of the 5-HT reuptake inhibitor Cericlamine.