133984-16-4Relevant academic research and scientific papers
Two-step synthesis of π-expanded maleimides from 3,4-diphenylfuran-2(5 H)-ones
Kang, Yang,Zhang, Wei,Wang, Tao,Liang, Yong,Zhang, Zunting
, p. 12387 - 12398 (2019/10/11)
An efficient two-step synthesis of -expanded maleimide derivatives was reported, which proceeded via a photoinduced dehydrogenative annulation of 3,4-diphenylfuran-2(5H)-ones in EtOH at room temperature for 5 h under an argon atmosphere, followed by inter
One-pot synthesis of 3,4-diaryl-substituted 2(5 H)-furanone and its commercial application
Argade, Anil,Desai, Jigar,Thombare, Pravin,Shah, Kiran,Gite, Sanjay,Prajapati, Vijay,Pandey, Bipin,Jain, Mukul,Patel, Pankaj,Bahekar, Rajesh
, p. 3140 - 3149 (2012/11/07)
One-pot synthesis of 3,4-diaryl substituted 2(5H)-furanones was established and its commercial application has been demonstrated by accomplishing total synthesis of rofecoxib, under mild reaction conditions, with good yields and purity.
Design and Synthesis of Novel Rofecoxib Analogs as Potential Cyclooxygenase (COX-2) Inhibitors: Replacement of the Methylsulfonyl Pharmacophore by a Sulfonylazide Bioisostere
Uddin, Md. Jashim,Rao, P.N. Praveen,Knaus, Edward E.
, p. 861 - 868 (2007/10/03)
A group of rofecoxib analogs, having a sulfonylazide (SO2N 3) substituent in place of the methanesulfonyl (SO2CH 3) pharmacophore at the meta-position viz 3-(4-methyl, 4-methoxy, or 4-ethoxyphenyl)-4-(3-sulfonyl
