13399-32-1Relevant academic research and scientific papers
Dual Intermolecular Allylic C–H Functionalization of the Tetrasubstituted Alkene Scaffold
Martínez, Claudio,Mu?iz, Kilian
, p. 1248 - 1254 (2018)
Activation of chloramine-T (TsNNaCl) with a Br?nsted acid generates an active reagent for the double allylic C–H functionalization of tetrasubstituted alkenes in an intermolecular manner. The reaction generates a carbon–nitrogen and a carbon–chlorine bond, and proceeds with complete regio- and chemoselectivity. A total of 14 examples demonstrate the applicability of the dual C–H functionalization process. The mechanism involves the intermediacy of a 1,3-butadiene derivative; 1,3-butadienes can also be used directly as substrates.
