133993-34-7Relevant academic research and scientific papers
NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS
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Paragraph 0298, (2019/01/21)
The present invention discloses compounds according to Formula (I) Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (SIP) receptor, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, inflammatory diseases, respiratory diseases, autoimmune diseases, metabolic diseases, cardiovascular diseases, and/or proliferative diseases by administering the compound of the invention.
Synthesis of dibenzocycloketones by acyl radical cyclization from aromatic carboxylic acids using methylene blue as a photocatalyst
Jiang, Hongshuo,Mao, Guijie,Wu, Hongfeng,An, Qi,Zuo, Minghui,Guo, Weihao,Xu, Chunzhao,Sun, Zhizhong,Chu, Wenyi
supporting information, p. 5368 - 5373 (2019/10/11)
An efficient intramolecular radical cyclization reaction via photoredox catalysis was developed for the synthesis of dibenzocycloketone derivatives using methylene blue as a photosensitizer. This strategy could be widely used to synthesize large heterocycles due to the unique reactivity of phosphoranyl radicals formed by a polar/SET crossover between an aromatic carboxylic acid and a phosphine radical cation. Attractive features of this process include generation of an acyl radical by an inexpensive and metal-free photocatalyst, which effectively undergoes a cyclization process.
Synthesis of New Benzofuro and Indolobenzoazepin-6-ones
Viti, Giovanni,Giannotti, Danilo,Nannicini, Rossano,Ricci, Renzo,Pestellini, Vittorio
, p. 379 - 384 (2007/10/02)
Three new tetracyclic structures, containing the azepine ring, were synthesized: 11,12-dihydro-6H-benzofurobenzoazepine-6,11-dione, 5,6,11,12-tetrahydroindolobenzoazepine-6,11-dione and 11,12-dihydro-6H-benzofurobenzoazepin-6
