1339960-64-3

Upstream product

• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 1339960-58-5 tert-butyl (4R)-4-[(1S)-3-hydroxy-1,3-dihydroisobenzofuran-1-yl]-2,2-dimethyloxazolidine-3-carboxylate 
• 108-98-5 thiophenol 
• 1339960-57-4 tert-butyl (R)-4-{(S)-[2-(1,3-dioxan-2-yl)phenyl](hydroxy)methyl}-2,2-dimethyloxazolidine-3-carboxylate 
• 871725-95-0 bromo[2-(1,3-dioxan-2-yl)phenyl]magnesium 

Relevant academic research and scientific papers

Diversity-oriented synthesis of functionalized polyheterocycles from Garner aldehyde

We report a diversity-oriented synthesis of diverse drug-like polyheterocycles from Garner aldehyde derived 1-hydroxy-1,3-dihydroisobenzofuran 20 as a key intermediate. The oxonium-mediated nucleophilic addition of 20 in the presence of boron tri-fluoride-diethyl ether complex provided enantiopure 1,3-disubstituted 1,3-dihydroisobenzofurans through 1,3-asymmetric induction. Further diversification of 20 allowed the diastereoselective syntheses of drug-like polyheterocycles including the 3-substituted isobenzofuran-1(3H)-one, 2,3-dihydro-1H-isoindol-1-one, and 3,4-disubstituted dihydroisoquinolinone ring systems. Georg Thieme Verlag Stuttgart ? New York.