134-31-6

Basic information

• Product Name: 8-Hydroxyquinoline sulfate
• Synonyms: Quinolin-1-ium-8-ol sulfate;8-Quinolinol·0.5sulfuric acid;8-Quinolinol hemisulfate salt,8-Hydroxyquinoline hemisulfate salt;8-Hydroxyquinoline sulfate, synthesis grade;Oxyquinoline Sulfate (200 mg);8-Quinophenol sulfate;8-Quinolinol Sulfate Chinosol 8-Hydroxyquinoline Sulfate Oxine Sulfate 8-Quinolinone Sulfate
• CAS NO: 134-31-6
• Molecular Formula: 2C9H7NO.H2O4S
• Molecular Weight: 388.4
• EINECS: 205-137-1
• Product Categories: strong pincer compound;Quinoline derivatives;Hydroxyquinolines;Quinolines
• Mol File: 134-31-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: ~175 °C
• Boiling Point: 267 °C at 760 mmHg
• Flash Point: 143.1 °C
• Appearance: yellow/crystalline
• Density: 1.3819 (rough estimate)
• Vapor Pressure: 8.34E-14mmHg at 25°C
• Refractive Index: 1.5364 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: >=10 g/100 mL at 19 ºC
• Merck: 14,4843
• BRN: 3760550
• CAS DataBase Reference: 8-Hydroxyquinoline sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Hydroxyquinoline sulfate(134-31-6)
• EPA Substance Registry System: 8-Hydroxyquinoline sulfate(134-31-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• RIDADR: 2811
• WGK Germany: 1
• RTECS: VC8260000
• F: 3-10
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 134-31-6(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline

Originator

Chinosol,Chinosolfabrik

Uses

Different sources of media describe the Uses of 134-31-6 differently. You can refer to the following data:
1. Pharmaceutic aid (complexing agent).
2. oxyquinoline sulfate is a disinfectant and a preservative against fungus growth. It is made from phenols.
3. 8-Hydroxyquinoline sulfate is used to control grey mould (Botrytis cinevea) in vine grafting. It is also used as a soil sterilant against damping off in seed beds.

Manufacturing Process

The mixture of 1.4 kg o-nitrophenol, 2.1 kg o-aminophenol, 6 kg glycerine (d = 1.26) and 5 kg sulfuric acid (d = 1.848) was heated at reflux to temperature 130°-140°C. This temperature was kept for 1.5 hours. The obtained oxyquinoline precipitated, the liquid was removed with water-steam distillation. The residue was diluted with water and alkalized with sodium hydroxide and sodium carbonate to the strong alkaline reaction. The repeated distillation with water steam gave the oil, which hardened as the long needles by cooling. MP: 75°-76°C recrystallized from diluted ethanol. In practice it is usually used as sulfate salt

Therapeutic Function

Antiseptic

General Description

Pale yellow to yellow crystalline powder with a slight saffron odor. Burning taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

A sulfate acidic salt of an amine that is also a phenol. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Fire Hazard

Flash point data for 8-Hydroxyquinoline sulfate are not available, but 8-Hydroxyquinoline sulfate is probably combustible.

Flammability and Explosibility

Notclassified

Metabolic pathway

Little published information is available.

Degradation

The salt and free base of 8-hydroxyquinoline sulfate are very stable but alkali liberates quinolin-8-ol which precipitates heavy metals (PM). 8-Hydroxyquinoline is a chelate ligand of transition metals such as copper.

InChI:InChI=1/C9H7NO.H2O4S/c11-9-6-5-7-3-1-2-4-8(7)10-9;1-5(2,3)4/h1-6H,(H,10,11);(H2,1,2,3,4)

Related news

Disinfective Activity of 8-Hydroxyquinoline sulfate (cas 134-31-6) on Moulds09/30/2019

The aim of conducted research was the estimation of 8-hydroxyquinoline sulfate activity on selected mould strains isolated from the buildings with biodeterioration evidence. In the tests for the fungicidal activity, 6 working concentrations rangeing from 0.01 % to 1.0 % of 8-hydroxyquinoline sul...detailed

High-performance liquid chromatographic assay of 8-Hydroxyquinoline sulfate (cas 134-31-6) and its stability in immunobiological preparations10/01/2019

Because of the ability of 8-hydroxyquinoline sulfate (8-HQS) to irreversibly bind metals from rubber stoppers, the stability of 8-HQS in tuberculin solutions was investigated. For the determination of 8-HQS, a simple and sensitive reversed-phase HPLC method with detection at 240 nm was developed...detailed