134-35-0

Basic information

• Product Name: 5-Methyltetrahydrofolicacid
• Synonyms: Glutamicacid, N-[p-[[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-5-methyl-6-pteridinyl)methyl]amino]benzoyl]-(6CI);Glutamic acid,N-[p-[[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-5-methyl-6-pteridinyl)methyl]amino]benzoyl]-,L- (8CI);L-Glutamic acid,N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-(9CI);5-Methyl-5,6,7,8-tetrahydrofolic acid;5-Methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid;L-Glutamic acid,N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-;5-Methyltetrahydropteroyl monoglutamate;5-Methyltetrahydropteroylglutamic acid;N-Methyltetrahydrofolate;N-Methyltetrahydrofolic acid;N5-Methyltetrahydrofolate;N5-Methyltetrahydrofolic acid;N5-Methyltetrahydropteroylglutamate;Prefolic A
• CAS NO: 134-35-0
• Molecular Formula: C₂₀H₂₅N₇O₆
• Molecular Weight: 454.4161
• EINECS: 1592732-453-0
• Product Categories: Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Nucleotides;Pharmaceuticals
• Mol File: 134-35-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: >300°C (dec.)
• Appearance: /
• Density: 1.62 g/cm³
• Refractive Index: 1.733
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Aqueous Base (Slightly, Sonicated)
• PKA: 3.51±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 5-Methyltetrahydrofolicacid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyltetrahydrofolicacid(134-35-0)
• EPA Substance Registry System: 5-Methyltetrahydrofolicacid(134-35-0)

Safety Data

• Hazardous Substances Data: 134-35-0(Hazardous Substances Data)

Usage

Description

5-Methyltetrahydrofolic acid (5-MTHF) is an active folate metabolite. It plays an important role in the synthesis of methionine from homocysteine by donating methyl group. 5-Methyltetrahydrofolic acid-(glutamic acid-13C5) is an isotope of vitamin B9 wherein all the five glutamate carbons are replaced by 13C6 carbon.

Supplements

5-Methyltetrahydrofolic acid is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid.

Mechanism of Action

Prefolic A, also known as 5-Methyltetrahydrofolate, is a biologically active form of folic acid that functions, in conjunction with vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine. Methyl folate is an active metabolite of folic acid. Vitamin supplement in health care products.

Shipping & Storage Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Stored in dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).Shelf Life can be more than 2 years if stored properly.

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 134-35-0 differently. You can refer to the following data:
1. 5-Methyltetrahydrofolic acid-(glutamic acid-13C5) can be used as a stable isotope internal standard for accurate data interpretation in citrus juice samples by LC-MS.
2. 5-Methyltetrahydrofolic acid is a metabolite of Folic acid; inhibits photosensitization reactions and strand breaks in DNA. 5-Methyltetrahydrofolic acid-(glutamic acid-13C5) can be used as a stable isotope internal standard for accurate data interpretation in citrus juice samples by LC-MS.

General Description

5-Methyltetrahydrofolic acid (5-MTHF) is an active folate metabolite. It plays an important role in the synthesis of methionine from homocysteine by donating methyl group.5-Methyltetrahydrofolic acid-(glutamic acid-13C5) is an isotope of vitamin B9 wherein all the five glutamate carbons are replaced by 13C6 carbon.

InChI:InChI=1/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12?,13-/m0/s1