134000-08-1

Basic information

• Product Name: 2-{1,1-Dimethyl-2-[4-((S)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione
• Synonyms: 2-{1,1-Dimethyl-2-[4-((S)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione
• CAS NO: 134000-08-1
• Molecular Weight: 404.469
• Mol File: 134000-08-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{1,1-Dimethyl-2-[4-((S)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{1,1-Dimethyl-2-[4-((S)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione(134000-08-1)
• EPA Substance Registry System: 2-{1,1-Dimethyl-2-[4-((S)-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione(134000-08-1)

Safety Data

• Hazardous Substances Data: 134000-08-1(Hazardous Substances Data)

Upstream product

• 15379-23-4 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-methylpropanal 
• 101328-84-1 (5S)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 
• 616-02-4 citraconic acid anhydride 
• 139052-03-2 3-(p-Acetamidobenzoyl)-crotonsaeure 
• 103-84-4 Acetanilid 
• 139052-01-0 (S)-4-(4-Acetylamino-phenyl)-3-methyl-4-oxo-butyric acid 
• 139128-27-1 N-[4-((S)-4-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-acetamide 

Downstream Products

• 134018-59-0 (S)-6-[4-(2-Amino-2-methyl-propylamino)-phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one 

Relevant articles and documents

Studies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665

Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether (3). The hypotensive and β-blocking activities of 1 and its optical isomers were examined when given intravenously into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III. Among the four optical isomers, R(A),S(B)-one (1c) possessed the essential activities of TZC-5665 (1).