134002-99-6

Upstream product

• 86852-11-1 diethoxyltriphenylphosphorane 
• 104762-38-1 (S)-4-methyl-2,2,2-triphenyl-1,2,2λ⁵-dioxaphospholane 
• 104-15-4 toluene-4-sulfonic acid 

Relevant academic research and scientific papers

The regioselective and stereospecific substitution of unsymmetrical 1,2-diols using the 1,3,2λ5-dioxaphospholane methodology

Stereo specific tosylate (-OTs) or azide (N3-) substitution at the C-4 stereocenter of a monosubstituted 1,3,2λ5-dioxaphospholane (the equivalent of the C-2 stereocenter in an unsymmetrical 1,2-diol) is readily achieved by treatment with either P-toluenesulfonic acid (P-TsOH) in tetrahydrofuran solvent or P-TsOH/sodium azide in acetonitrile solvent, respectively.