134023-36-2Relevant academic research and scientific papers
A series of C-terminal amino alcohol dipeptide Aβ inhibitors
Garofalo, Albert W.,Wone, David W.G.,Phuc, Angela,Audia, James E.,Bales, Cheryl A.,Dovey, Harry F.,Dressen, Darren B.,Folmer, Beverly,Goldbach, Erich G.,Guinn, Ashley C.,Latimer, Lee H.,Mabry, Thomas E.,Nissen, Jeffrey S.,Pleiss, Michael A.,Sohn, Stephen,Thorsett, Eugene D.,Tung, Jay S.,Wu, Jing
, p. 3051 - 3053 (2002)
Potent, small molecule Aβ inhibitors have been prepared that incorporate an alanine core bracketed by an N-terminal arylacetyl group and various C-terminal amino alcohols. The compounds exhibit stereospecific inhibition as demonstrated in an in vitro assa
A rapid and efficient synthesis of β-casomorphin employing Boc-amino acids and 9-fluorenylmethyl chloroformate as a coupling agent
Babu, V.V. Suresh,Tantry
, p. 2708 - 2712 (2007/10/03)
The synthesis of β-casomorphin H-Tyr-Pro-Phe-Pro-Gly-OH employing Boc group for Nα-protection and 9-fluorenylmethyl chloroformate (Fmoc-Cl) for the formation of peptide bond is described. The protocol employing Fmoc-Cl as coupling reagent is found to be simple, efficient and rapid. All the intermediate peptides as well as the final protected peptide Boc-Tyr( iBu)-Pro-Phe-Pro-Gly-OMe have been isolated and fully characterized. They have been obtained in good yield and with high purity.
