134028-03-8

Basic information

• Product Name: C₁₆H₁₆N₂O₆*C₁₉H₂₂N₂O
• Synonyms: C₁₆H₁₆N₂O₆*C₁₉H₂₂N₂O
• CAS NO: 134028-03-8
• Molecular Weight: 626.709
• Mol File: 134028-03-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₆N₂O₆*C₁₉H₂₂N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₆N₂O₆*C₁₉H₂₂N₂O(134028-03-8)
• EPA Substance Registry System: C₁₆H₁₆N₂O₆*C₁₉H₂₂N₂O(134028-03-8)

Safety Data

• Hazardous Substances Data: 134028-03-8(Hazardous Substances Data)

Upstream product

• 74936-72-4 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 
• 118-10-5 cinchonidine 

Downstream Products

• 76093-34-0 (+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid 

Relevant articles and documents

Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

An efficient total synthesis of (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate in high optical purities is reported. The useful step is the resolution of racemic 2, 6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid by using commercially available Cinchona alkaloids cinchonidine and quinidine as the resolving agents. Under the optimum conditions, the optical purities for R- and S-enantiomers are extremely high (ee >99.5%). The further dihydropyridine receptor binding activity assay shows that the S-enantiomer is more potent than R-enantiomer both in rat cardiac (approximately 19 times) and cerebral cortex membrane (12 times).