134031-87-1

Upstream product

• 164070-17-1 1-((2S,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 
• 4449-43-8 α-deoxythymidine 
• 158813-99-1 5'-O-acetyl-α-thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 201219-77-4 5'-O-acetyl-3'-O-(4,4'-dimethoxytrityl)-α-thymidine 
• 164070-21-7 1-[(2S,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

5'-END DERIVATIVES

The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

Targeting chimeric α,β-oligonucleotides to the flanks of a stem in DNA. The enhanced effect of an intercalator

3′-O-(4,4′-Dimethoxytrityl)-5-methyl-N 4-(1-pyrenylmethyl)-α-cytidine (7) was prepared from α-thymidine by the reaction of 1-pyrenylmethylamine with an appropriate protected 4-(1,2,4-triazolyl)-α-thymidine derivative 5. 3′-O-(4,4′-Dimethoxytrit

Synthesis and physicochemical properties of alternating α,β-oligodeoxyribonucleotides with alternating (3' → 3')- and (5' → 5')-internucleotide phosphodiester linkages

A simple and straightforward synthesis of α-2'-deoxycytidine and α-2'-deoxyadenosine derivatives 6a,b has been achieved from commercial N4-benzoyl-b-2'-deoxycytidine and N6-benzoyl-β-2'deoxyadenosine, respectively. Properly protected