134038-64-5Relevant academic research and scientific papers
Synthesis of agonists and antagonists for central glutamate receptors by a novel 'ring switching' strategy
Bowler, Andrew N.,Dinsmore, Andrew,Doyle, Paul M.,Young, Douglas W.
, p. 1297 - 1306 (2007/10/03)
A novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the β-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors.
