134038-91-8

Upstream product

• 186581-53-3 diazomethane 
• 111197-44-5 (4S)-4-(Chloroformyl)methyl-3-[(phenylmethoxy)carbonyl]oxazolidin-5-one 
• 1152-61-0 N-Cbz-L-Asp 
• 23632-66-8 (4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one 

Downstream Products

• 1237501-67-5 C₁₄H₁₄BrNO₅ 
• 134038-93-0 4-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>methylthiazole 
• 119434-75-2 (S)-3-(4-thiazolyl)-2-tert-butoxycarbonylaminopropanoic acid 
• 157695-66-4 (S)-2-Benzyloxycarbonylamino-5-hydroxy-4-oxo-pentanoic acid 
• 134038-92-9 1-<(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-chloro-2-propanone 

Relevant academic research and scientific papers

Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase

The antifungal activity of 5-hydroxy-4-oxo-l-norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV-containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI-1640 medium, with minimal inhibitory concentration values in the 32 to 64?μg?mL?1 range. This activity was not affected by multidrug resistance that is caused by overexpression of genes encoding drug efflux proteins. The mechanism of antifungal action of HONV dipeptides involved uptake by the oligopeptide transport system, subsequent intracellular cleavage by cytosolic peptidases, and inhibition of homoserine dehydrogenase by the released HONV. The relative transport rates determined the anticandidal activity of HONV dipeptides.

Ultrasound mediated synthesis of 2-amino-1,3-selenazoles derived from Fmoc/Boc/Z-α-amino acids

A simple and efficient one-pot synthesis of Fmoc/Boc/Z-amino acid derived 2-amino-1,3-selenazoles by the condensation of Nα-urethane protected amino acid derived bromomethyl ketones with selenourea under the influence of ultrasound has been described. Insertion of 2-amino-1,3-selenazole moiety in the side chains of Asp and Glu has also been achieved following the similar protocol. ARKAT USA, Inc.

SYNTHESIS OF CHIRAL LACTAMS AS TEMPLATES FOR ENZYME INHIBITORS: AN UNUSUAL ANNULATION IN THE INTRAMOLECULAR WADSWORTH-HORNER-EMMONS REACTION

Intramolecular carbonylolefination of a dipeptide keto phosphonate furnished unexpected lactams through rearrangement of the phosphonate carbanion.

Synthesis of N-(tert-Butoxycarbonyl)-3-(4-thiazolyl)-L-alanine

Efficient syntheses of N-(tert-butoxycarbonyl)-3-(4-thiazolyl)-L-alanine (11) are described.