134039-35-3Relevant academic research and scientific papers
Synthesis of 5-homoshikimic acid and some fluorinated derivatives as potential inhibitors of 5-enolpyruvylshikimate-3-phosphate synthase
Campbell,Mahon,Sainsbury,Searle,Davies
, p. 8751 - 8774 (2007/10/02)
The synthesis of (±)-5-homoshikimic acid, its 5-fluromethyl and difluoromethyl analogues are described from the cycloadducts of 5,6-dihydro-1-(t)butyloxycarbonylpyridine and methyl acrylate. The adducts on ring opening afford methyl 5-(t)butoxycarbonylmethyl-5,6-dihydrobenzoate, which may be 3,4-cis-dihydroxylated and converted in a series of steps into the title compounds.
SYNTHESIS OF (+/-)-HOMOGABACULINE AND (+/-)-HOMOSHIKIMIC ACID
Campbell, Malcolm M.,Mahon, Mary F.,Sainsbury, Malcolm,Searle, Philip A.,Davies, Gareth M.
, p. 951 - 954 (2007/10/02)
Syntheses of homogabaculine and homoshikimic acid are described using the base mediated ring opening of the cycloadducts of methyl acrylate and N-carbamoyl-1,2-dihydropyridines.
