134040-47-4

Upstream product

• 190127-96-9 9-((2R,3S,4S,5R,6R)-4-Allyloxy-6-allyloxymethyl-3,5-bis-benzyloxy-tetrahydro-pyran-2-yloxy)-nonanoic acid methyl ester 
• 34957-73-8 methyl 9-hydroxynonanoate 
• 86861-46-3 3,6-di-O-acetyl-2,4-di-O-benzyl-α-D-mannopyranosyl bromide 
• 108167-20-0 8-(methoxycarbonyl)octyl 2,4-di-O-benzyl-α-D-mannopyranoside 
• 81413-15-2 8-methoxycarbonyloctyl 3,6-di-O-benzyl-D-mannopyranoside 
• 193337-63-2 (2R,3R,4S,5S)-4-Allyloxy-2-allyloxymethyl-3,5-bis-benzyloxy-6-bromo-tetrahydro-pyran 
• 86032-57-7 3,6-di-O-allyl-2,4-di-O-benzyl-α-D-mannopyranosyl acetate 

Downstream Products

• 171192-42-0 9-[(2R,3S,4S,5S,6R)-3,5-Bis-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-pyran-2-yloxy]-nonanoic acid methyl ester 
• 134040-48-5 8-methoxycarbonyloctyl 2,4-di-O-benzyl-3,6-di-O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-β-D-mannopyranoside 

Relevant academic research and scientific papers

A new strategy for oligosaccharide assembly exploiting cyclohexane-1,2-diacetal methodology: An efficient synthesis of a high mannose type nonasaccharide

The high-mannose nonasaccharide 1 is part of the glycoprotein gp 120 of the viral coat of HIV-1. The mannan portion of this triantennary glycan was prepared by a number of consecutive glycosidation steps without the need for any protecting-group manipulat

Use of N-acetylglucosaminyltransferases I and II in the preparative synthesis of oligosaccharides.

8-Methoxycarbonyloctyl 3,5-di-O-(alpha-D-mannopyranosyl)-beta-D-mannopyranoside (1) has been synthesised chemically. Compound 1 is a substrate for N-acetylglucosaminyltransferase-I (GlcNAcT-I), which transfers a beta-D-GlcpNAc residue from UDP-GlcpNAc to position 2 of the alpha-Man-(1----3) unit to produce 2. In turn, the tetrasaccharide 2 is an acceptor for GlcNAcT-II which, in the presence of UDP-GlcpNAc, converts 2 into 8-methoxycarbonyloctyl 3,6-di-O-[2-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-alpha-D- mannopyranosyl]-beta-D-mannopyranoside (3). These conversions were carried out on a 50-100 mg scale using enzyme preparations obtained from rabbit liver in a single step by affinity chromatography.