1340480-83-2

Upstream product

• 24237-54-5 tinoridine 
• 1340480-82-1 ethyl 6-benzyl-2-((triphenylphosphoranylidene)amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 1364804-66-9 C₂₆H₂₈N₄OS 
• 1364804-69-2 7-benzyl-2-(diethylamino)-3-phenyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 1364804-82-9 C₂₃H₂₁N₃O₂S 
• 1364804-85-2 C₂₄H₂₃N₃O₂S 
• 1364805-60-6 C₂₈H₃₄N₄O₂S 
• 1364805-56-0 C₂₈H₃₄N₄O₂S 
• 1364804-91-0 C₂₈H₂₃N₃O₂S 
• 893683-63-1 3-amino-2-phenylamino-7-benzyl-5,6,7,8-tetrahydropyrido[4′,3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 1609253-99-7 7-benzyl-3-phenyl-2-(piperidin-1-yl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 1609274-95-4 (E)-ethyl 6-benzyl-2-(((phenylamino)(pyrrolidin-1-yl)methylene)amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate 

Relevant academic research and scientific papers

Synthesis, characterization and crystal structure of heterocyclic tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidinone derivatives via sequential aza-Wittig/base catalyzed cyclization

Seventeen examples of 7-Benzyl-5,6,7,8-tetrahydropyrido [4′,3′:4,5]thieno [2,3-d]pyrimidin-4(3H) -ones were synthesized by base catalyzed reactions of nucleophilic reagents (aliphatic amines, alcohols or phenols) with carbodiimides 3, which in turn were obtained by the aza-Wittig reaction of iminophosphorane 2 with aromatic isocyanates. The compounds were fully characterized by analytical and spectroscopic techniques (FT-IR, 1H NMR, 13C NMR and MS). Crystal structure determination of three tetrahydropyrido [4′,3':4,5]thieno [2,3-d]pyrimidinone derivatives has been undertaken in order to better understanding the influence of structural modifications upon overall molecular geometry and conformation. 3D supramolecular architectures are formed in the crystals by self-assembly of the molecules via stacking interactions and various hydrogen bonds. Meanwhile, crystal structure of a guanidine intermediate 4a was characterized in order to proclaim the reaction mechanism of the base catalyzed intramolecular cycloaddition.

Facile synthesis of thieno[2,3-d]pyrimidine derivatives using inorganic base catalysis

Potassium carbonate as inorganic base catalyst was used to develop an efficient synthetic procedure for the preparation of thieno[2,3-d]pyrimidine derivatives. The molecular structure of the newly synthesized compounds were confirmed by NMR spectral data.

Efficient synthesis of thieno[2,3-d]pyrimidin-4(3H)-ones by a sequential aza-Wittig reaction/base catalyzed cyclization

7-Benzyl-5,6,7,8-tetrahydropyrido[4 ' ,3 ' :4,5]thieno[2,3-d] pyrimidin-4(3 H)-ones were synthesized by base catalyzed reactions of nucleophilic reagents (aliphatic amines, alcohols or phenols) with carbodiimides 4 , which in turn were obtained by the aza-Wittig reaction of iminophosphoranes 3 with aromatic isocyanates. 2011 · Copyright by Walter de Gruyter.

Efficient synthesis of 7-benzyl-5,6,7,8-tetrahydropyrido[4′,3′: 4,5]thieno [2,3-d]pyrimidin-4(3H)-ones via aza-Wittig reaction

7-benzyl-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d] pyrimidin-4(3H)-ones were synthesized by base catalytic reactions of nucleophilic reagents (aliphatic amines, alcohols or phenols) with carbodiimides 4, which were obtained from the aza-Wittig reaction of iminophosphoranes 3 with aromatic isocyanates.