1340587-19-0

Basic information

• Product Name: N-([2-(3-fluorobenzoyl)hydrazinyl]methylene)pyrazine-2-carboxamide
• Synonyms: N-([2-(3-fluorobenzoyl)hydrazinyl]methylene)pyrazine-2-carboxamide
• CAS NO: 1340587-19-0
• Molecular Weight: 287.253
• Mol File: 1340587-19-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-([2-(3-fluorobenzoyl)hydrazinyl]methylene)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-([2-(3-fluorobenzoyl)hydrazinyl]methylene)pyrazine-2-carboxamide(1340587-19-0)
• EPA Substance Registry System: N-([2-(3-fluorobenzoyl)hydrazinyl]methylene)pyrazine-2-carboxamide(1340587-19-0)

Safety Data

• Hazardous Substances Data: 1340587-19-0(Hazardous Substances Data)

Upstream product

• 78132-02-2 N-[(dimethylamino)methylene]pyrazine-2-carboxamide 
• 499-55-8 3-fluoro-benzoic acid hydrazide 

Relevant articles and documents

New fluorine-containing hydrazones active against MDR-tuberculosis

Several new fluorine-containing hydrazones were synthesized and screened for their in vitro antimycobacterial activity. Nine of these derivatives have shown a remarkable activity against MDR-TB strain with MIC 0.5 μg/mL and high value of selectivity index (SI). Compound 3h with the highest SI (1268.58) was used for stability evaluation with putative metabolites (ciprofloxacin and formylciprofloxacin) detection. Compound 3h was stable at pH 7.4 of aqueous buffer and rat plasma, in acidic buffers (at pH 3 and 5) slow decomposition was observed. Interestingly, no formylciprofloxacin was detected in the solution, and only slightly increased concentration of ciprofloxacin was observed instead. Trifluoromethyl hydrazones 3f and 3g exhibited the best activity also against two strains of Mycobacterium kansasii (MIC 1-4 μmol/L). All evaluated compounds were found to be non-cytotoxic.