1340592-98-4Relevant academic research and scientific papers
Indole functionalization via photoredox gold catalysis
Kaldas, Sherif J.,Cannillo, Alexandre,McCallum, Terry,Barriault, Louis
supporting information, p. 2864 - 2866 (2015/06/16)
The use of photoredox catalyst [Au2(dppm)2]Cl2 to initiate free-radical cyclizations onto indoles is reported. Excitation of the dimeric Au(I) photocatalyst for the reduction of unactivated bromoalkanes and bromoarenes is used for the generation of carbon-centered radicals. Previous to this work, reduction processes leading to indole functionalization utilizing photoredox catalysts were limited to activated benzylic or α-carbonyl-positioned bromoalkanes. This method offers a mild and safe alternative to organostannanes and pyrophoric initiators for access to high energy radicals that were previously inaccessible through catalytic or stoichiometric means.
Synthesis and pharmacological evaluation of indole-based sigma receptor ligands
Mésangeau, Christophe,Amata, Emanuele,Alsharif, Walid,Seminerio, Michael J.,Robson, Matthew J.,Matsumoto, Rae R.,Poupaert, Jacques H.,McCurdy, Christopher R.
, p. 5154 - 5161 (2011/11/29)
A series of novel indole-based analogs were prepared and their affinities for sigma receptors were determined using in vitro radioligand binding assays. The results of this study identified several compounds with nanomolar sigma-2 affinity and significant
