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134069-66-2

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134069-66-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 134069-66-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,0,6 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 134069-66:
(8*1)+(7*3)+(6*4)+(5*0)+(4*6)+(3*9)+(2*6)+(1*6)=122
122 % 10 = 2
So 134069-66-2 is a valid CAS Registry Number.

134069-66-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-[2-(4-fluorophenyl)ethyl]-4-methylidene-3-phenyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

1.2 Other means of identification

Product number -
Other names 8-[2-(4-fluorophenyl)ethyl]-1-methylidene-2-phenyl-4-oxa-2,8-diazaspiro[4.5]decan-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134069-66-2 SDS

134069-66-2Downstream Products

134069-66-2Relevant articles and documents

1-Oxa-3,8-diazaspiro[4.5]decan-2-one derivatives with a potent inhibitory effect on neural Ca-uptake and protecting action against TET-induced brain edema and memory and learning deficits

Toth,Kiss,Gere,Karpati,Toerley,Palosi,Kis-Varga,Paroczai,Szabo,Groo,Laszlovszky,Lapis,Csomor,Szporny

, p. 27 - 38 (2007/10/03)

A series of novel 1-oxa-3,8-diazaspiro[4.5]decan-2-one derivatives 8-71 were synthesized. Several representatives were examined for their in vitro inhibitory action on 45Ca-uptake into cerebrocortical synaptosomes depolarized by potassium and veratrine and on triethyltin-induced brain edema. Of the compounds displaying most potent inhibitory action on veratrine-induced 45Ca-uptake into cerebrocortical synaptosomes and outstanding protection against triethyltin chloride (TET) induced brain edema in rats, four were tested for their antihypoxic action and prevention of learning and memory deficits elicited by various agents (eg, electroshock, diazepam, scopolamine, carbon dioxide and normobaric hypoxia). In some of these tests the four compounds showed remarkable protecting/restoring activity. It is assumed that the beneficial effects of these compounds in brain edema formation are probably related to their actions on intracellular Ca2+- and Na+-movements. These cellular effects may also play role in their antiamnesic actions, but other mechanisms may also be involved. On the basis of results obtained in the tests used, the pharmacological profile of the novel 1-oxa-3,8-diazaspiro[4.5]decan-2-one derivatives seems to differ from that of known Ca2+-antagonists such as flunarizine or nimodipine and Na+-channel blocker, phenytoin. Out of the four most active compounds tested, one (44) was selected for further investigation and this compound is currently under preclinical development with the code name of RGH-2716 or TDN-345.

1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives, pharmaceutical compositions containing them and process for preparing same

-

, (2008/06/13)

The invention relates to novel compounds 1-oxa-2-oxo-8- of the formula (I), STR1 wherein X means oxygen or an >NR group, wherein R stands for hydrogen, a C1-12 alkyl, C3-6 cycloalkyl, carbocyclic C6-10 aryl or carbocyclic

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