1340875-16-2

Usage

Uses

Used in Pharmaceutical Industry:
(4-trifluoromethylphenyl)(pyridin-3-yl)methanol serves as a crucial building block in the synthesis of various pharmaceuticals. Its unique structural features allow it to be a versatile component in the creation of new drugs, enhancing their efficacy and selectivity for targeted biological processes.
Used in Agrochemical Industry:
In the agrochemical sector, (4-trifluoromethylphenyl)(pyridin-3-yl)methanol is utilized for the development of novel agrochemicals. Its incorporation into these products can lead to improved performance and selectivity, contributing to more effective pest control and crop protection strategies.
Used in Medicinal Chemistry Research:
(4-trifluoromethylphenyl)(pyridin-3-yl)methanol is also employed as a valuable tool in medicinal chemistry research. Its ability to modulate biological activity makes it instrumental in studying various biological processes and pathways, which can lead to the discovery of new therapeutic targets and treatments.
Overall, (4-trifluoromethylphenyl)(pyridin-3-yl)methanol is a multifaceted chemical with a broad spectrum of applications, particularly in the advancement of drug discovery and the development of new chemical entities for various industries.

Upstream product

• 21221-92-1 (pyridin-3-yl)(4-(trifluoromethyl)phenyl)methanone 

Downstream Products

• 1430341-11-9 C₂₂H₂₆F₃N₃O₂ 
• 1430341-31-3 3-(chloro[4-(trifluoromethyl)phenyl]methyl)pyridine 
• 1430340-81-0 C₂₂H₂₆F₃N₃O 
• 1430341-00-6 C₁₈H₂₀F₃N₃O₂S 

Relevant academic research and scientific papers

METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T

The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

A scaffold hopping exercise undertaken to expand the structural diversity of the fenarimol series of anti-Trypanosoma cruzi (T. cruzi) compounds led to preparation of simple 1-[phenyl(pyridin-3-yl)methyl]piperazinyl analogues of fenarimol which were investigated for their ability to inhibit T. cruzi in vitro in a whole organism assay. A range of compounds bearing amide, sulfonamide, carbamate/carbonate and aryl moieties exhibited low nM activities and two analogues were further studied for in vivo efficacy in a mouse model of T. cruzi infection. One compound, the citrate salt of 37, was efficacious in a mouse model of acute T. cruzi infection after once daily oral dosing at 20, 50 and 100 mg/kg for 5 days.