134088-74-7 Usage
Description
Nartograstim, a highly active mutein of the granulocyte colony-stimulating factor
(G-CSF) produced by recombinant technology, was introduced in Japan for the
treatment of chemotherapy-induced granulocytopenia, rhabdomyosarcoma and
neutropenia associated with infantile acute lymphatic leukemia and infantile aplastic
anemia. In mice, nartograstim showed an excellent accelerating effect on rapid
recovery from severe leukopenia induced by typical anticancer agents such as
mitomycin C and adriamycin. In patients with advanced lung cancer, nartograstim
has been reported to produce a significant shortening of the period of neutropenia
and an acceleration of neutrophil count recovery. With changes of five amino acids
at the N-terminal region of human G-CSF, nartograstim has superior in vivo
hematopoietic effects to the intact rhG-CSF due to its higher specific activity to
progenitor cells and its improved physicochemical, biological and pharmacokinetic
stability.
Originator
Kyowa Hakko (Japan)
Brand name
Neu-Up
Check Digit Verification of cas no
The CAS Registry Mumber 134088-74-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,0,8 and 8 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134088-74:
(8*1)+(7*3)+(6*4)+(5*0)+(4*8)+(3*8)+(2*7)+(1*4)=127
127 % 10 = 7
So 134088-74-7 is a valid CAS Registry Number.