134099-20-0 Usage
Uses
Used in Pharmaceutical Industry:
2,3-Difluoro-4-(trifluoromethyl)benzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to impart specific biological activities to the final drug molecules. Its unique fluorinated structure contributes to the enhancement of drug properties such as potency, selectivity, and metabolic stability.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-Difluoro-4-(trifluoromethyl)benzaldehyde serves as a crucial building block in the development of new pesticides and herbicides. Its incorporation into these compounds can lead to improved effectiveness against pests and weeds, as well as increased selectivity and reduced environmental impact.
Used in Organic Chemistry Research:
2,3-Difluoro-4-(trifluoromethyl)benzaldehyde is utilized as a reagent in organic chemistry for its role in facilitating the formation of carbon-carbon bonds and the creation of other fluorinated compounds. Its presence in reactions can lead to the development of novel organic molecules with potential applications in various fields.
Handling and Storage:
Due to its potential hazards in handling and storage, 2,3-Difluoro-4-(trifluoromethyl)benzaldehyde should be managed with care. Proper safety measures, including the use of personal protective equipment and adherence to storage guidelines, are essential to minimize risks associated with its strong odor and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 134099-20-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,0,9 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 134099-20:
(8*1)+(7*3)+(6*4)+(5*0)+(4*9)+(3*9)+(2*2)+(1*0)=120
120 % 10 = 0
So 134099-20-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H3F5O/c9-6-4(3-14)1-2-5(7(6)10)8(11,12)13/h1-3H
134099-20-0Relevant academic research and scientific papers
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E
Hirayama, Takaharu,Okaniwa, Masanori,Banno, Hiroshi,Kakei, Hiroyuki,Ohashi, Akihiro,Ohori, Momoko,Nambu, Tadahiro,Iwai, Kenichi,Kawamoto, Tomohiro,Yokota, Akihiro,Miyamoto, Maki,Ishikawa, Tomoyasu
supporting information, p. 4296 - 4300 (2016/08/18)
Centromere-associated protein-E (CENP-E) is a mitotic kinesin which plays roles in cell division, and is regarded as a promising therapeutic target for the next generation of anti-mitotic agents. We designed novel fused bicyclic CENP-E inhibitors starting from previous reported dihydrobenzofuran derivative (S)-(+)-1. Our design concept was to adjust the electron density distribution on the benzene ring of the dihydrobenzofuran moiety to increase the positive charge for targeting the negatively charged L5 loop of CENP-E, using predictions from electrostatic potential map (EPM) analysis. For the efficient synthesis of our 2,3-dihydro-1-benzothiophene 1,1-dioxide derivatives, a new synthetic method was developed. As a result, we discovered 6-cyano-7-trifluoromethyl-2,3-dihydro-1-benzothiophene 1,1-dioxide derivative (+)-5d (Compound A) as a potent CENP-E inhibitor with promising potential for in vivo activity. In this Letter, we discuss the design and synthetic strategy used in the discovery of (+)-5d and structure–activity relationships for its analogs possessing various fused bicyclic L5 binding moieties.
