134111-36-7

Upstream product

• 108-24-7 acetic anhydride 
• 68660-42-4 C₂₂H₂₄O₅S 
• 874-60-2 4-methyl-benzoyl chloride 
• 68736-33-4 (2R,3S)-2-Hydroxymethyl-5-methoxy-tetrahydro-thiophen-3-ol 
• 1600-27-7 mercury(II) diacetate 
• 134939-04-1 benzyl 2-deoxy-1,4-dithio-3,5-di-O-p-toluoyl-D-erythro-pentofuranoside 

Relevant academic research and scientific papers

Efficient syntheses of (E)-5-(2-Bromovinyl)-2'-deoxy-4'thiouridine; a nucleoside analogue with potent biological activity

(E)-5-(2-Bromovinyl)-2'-deoxy-4'-thiouridine (S-BVDU) is a potent antiherpesvirus agent and its use in gene therapy as an anticancer agent has recently been described. We here outline 2 efficient methods for the synthesis of S-BVDU. The decision as to which method is to be used depends upon the starting materials available but starting from BVU, an overall yield of β-nucleoside of 35% can be expected. From 5-ethyl-2'deoxy-4'- thiouridine, radical bromination using bromine will give a quantitative conversion to S-BVDU if unreacted starting material is recycled (50%) or using N-bromosuccinimide, a one step yield in excess of 80% can be obtained.

Synthesis and Biological Activity of 2'-Deoxy-4'-thio Pyrimidine Nucleosides

2'-Deoxy-4'-thiocytidine (7β), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro.All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also act