134111-40-3Relevant academic research and scientific papers
The synthesis and biological activity of certain 4'-thionucleosides
Secrist III,Parker,Tiwari,Messini,Shaddix,Rose,Bennett Jr.,Montgomery
, p. 675 - 686 (2007/10/02)
Results are presented on the synthesis and biological activity of several types of 4'-thionucleosides as potential anticancer agents. Detailed studies on the mechanism of action of 4'-thiothymidine are also presented.
Synthesis and Biological Activity of 2'-Deoxy-4'-thio Pyrimidine Nucleosides
Secrist, John A.,Tiwari, Kamal N.,Riordan, James M.,Montgomery, John A.
, p. 2361 - 2366 (2007/10/02)
2'-Deoxy-4'-thiocytidine (7β), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro.All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also act
