1341126-06-4Relevant academic research and scientific papers
A versatile difluorovinylation method: Cross-coupling reactions of the 2,2-difluorovinylzinc-TMEDA complex with alkenyl, alkynyl, allyl, and benzyl halides Dedicated to Professor Iwao Ojima on the occasion of his 70th birthday.
Ichitsuka, Tomohiro,Takanohashi, Tsuyoshi,Fujita, Takeshi,Ichikawa, Junji
, p. 29 - 37 (2015)
A thermally stable 2,2-difluorovinylzinc-TMEDA complex was prepared via a deprotonation-transmetallation sequence starting from commercially available 1,1-difluoroethylene. The complex thus formed was successfully applied to transition metal-catalyzed cross-coupling reactions with a wide range of organic halides, which led to the syntheses of 2,2-difluorovinyl compounds. On treatment with the difluorovinylzinc-TMEDA complex in the presence of an appropriate palladium or copper catalyst, alkenyl, alkynyl, allyl, and benzyl halides effectively underwent difluorovinylation to afford 1,1-difluoro-1,3-dienes, 1,1-difluoro-1,3-enynes, 1,1-difluoro-1,4-dienes, and (3,3-difluoroallyl)arenes, respectively.
Facile synthesis of β,β-difluorostyrenes via the negishi coupling of thermally stable 2,2-difluorovinyl zincTMEDA complex
Fujita, Takeshi,Ichitsuka, Tomohiro,Fuchibe, Kohei,Ichikawa, Junji
, p. 986 - 988 (2011/12/05)
2,2-Difluorovinylzinc chlorideTMEDA complex, readily prepared from 1,1-difluoroethylene, undergoes the palladiumcatalyzed coupling reaction with aryl halides to afford β,β- difluorostyrenes in high yield. This reaction not only proceeds smoothly with ster
