134115-60-9Relevant academic research and scientific papers
Regiodivergent 1,4 versus 1,6 asymmetric copper-catalyzed conjugate addition
Henon, Helene,Mauduit, Marc,Alexakis, Alexandre
supporting information; experimental part, p. 9122 - 9124 (2009/02/08)
(Chemical Equation Presented) Metal matters: A highly regiodivergent copper-catalyzed asymmetric conjugate addition to α,β and γ,δ Michael acceptors is described. Zinc and aluminum reagents afford the 1,6 adduct with good to moderate enantioselectivity in the presence of ligand 1 (see scheme). In contrast, Grignard reagents used with hydroxy imidazolium ligand 2 afforded the 1,4 adduct with excellent ee values.
