1341198-48-8

Upstream product

• 17754-90-4 4-(Diethylamino)salicylaldehyde 
• 74317-53-6 rhodamine B hydrazide 
• 81-88-9 rhodamine B 

Relevant academic research and scientific papers

The synthesis and mercury-recognizing skill of two emission "turn-on" rhodamine derivatives excited by rare earth up-conversion lattice

The present paper focused on the synthesis and Hg(II)-sensing behavior of two rhodamine derived probes. Up-conversion NaYF4 nanocrystals were constructed and applied as the excitation host so that those probes could be lightened by the 980 nm e

Label-free sensing platform for miRNA-146a based on chromo-fluorogenic pyrophosphate recognition

In this study we applied the dual-responsive chromo-fluorescent Cu2+ chelate 1C for the recognition of miRNA-146a through a pyrophosphate (PPi) sensing strategy in a rolling circle amplification (RCA) process. This approach for the recognition of miRNA-146a was highly robust, selective, and sensitive down to the attomolar (fluorogenic) and sub-micromolar (chromogenic) ranges under modified biochemical conditions at elevated temperature. Probe 1 selectively recognized Cu2+ and PPi ions in a sequential manner, as evidenced by colorless→pink→colorless transitions; the fluorescence emissions centered at 480 nm underwent a corresponding on–off–on sequence in the bluish-green region. We attribute this reversible switching upon the addition of Cu2+/PPi ions to effective chelation-induced ligand-to-metal charge/electron transfer that resulted in opening of the lactam ring upon complexation and closing of the lactam ring upon decomplexation. We also report a label-free approach for monitoring miRNA-146a amplification in an RCA process under modified T4 ligase and ?29 buffer conditions, using the Cu2+ ensemble 1C at pH 7.0 (4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid: HEPES, 10 mM MgCl2); the time required to perform this process (40–50 min) was relatively shorter than conventional RCA process. This ensemble 1C could recognize miRNA-146a colorimetrically (from pink to colorless) and fluorimetrically (“turn-on” mode) at concentrations within the highly sensitive atto-/nanomolar range under physiological conditions. This cost-effective label-free sensing strategy appears to be a universal method for detecting miRNAs according to the specified length of the template.

New fluorescent probe based on rhodamine derivative for detection of both Cu2+ and L-Methionine and living cells imaging

This paper developed a new fluorescent rhodamine-based derivatives (RAD) probe for highly sensitive and selective detection of Cu2+ and L-Methionine (L-Met). The detection limits can reach as low as 12 nM for Cu2+ and 5 nM for L-Met, In addition, the RAD probe can be further applied to cell imaging owing to its photostability and low cytotoxicity.

Novel rhodamine probe as well as synthesis method and application thereof

The invention relates to a novel rhodamine probe as well as a synthesis method and application thereof. The preparation method of the novel rhodamine probe comprises the following steps of synthesizing an intermediate product rhodamine B hydrazide from rh

Reversible photochromic system based on rhodamine B salicylaldehyde hydrazone metal complex

Photochromic molecules are widely applied in chemistry, physics, biology, and materials science. Although a few photochromic systems have been developed before, their applications are still limited by complicated synthesis, low fatigue resistance, or incomplete light conversion. Rhodamine is a class of dyes with excellent optical properties including long-wavelength absorption, large absorption coefficient, and high photostability in its ring-open form. It is an ideal chromophore for the development of new photochromic systems. However, known photochromic rhodamine derivatives, such as amides, exhibit only millisecond lifetimes in their colored ring-open forms, making their application very limited and difficult. In this work, rhodamine B salicylaldehyde hydrazone metal complex was found to undergo intramolecular ring-open reactions upon UV irradiation, which led to a distinct color and fluorescence change both in solution and in solid matrix. The complex showed good fatigue resistance for the reversible photochromism and long lifetime for the ring-open state. Interestingly, the thermal bleaching rate was tunable by using different metal ions, temperatures, solvents, and chemical substitutions. It was proposed that UV light promoted isomerization of the rhodamine B derivative from enol-form to keto-form, which induced ring-opening of the rhodamine spirolactam in the complex to generate color. The photochromic system was successfully applied for photoprinting and UV strength measurement in the solid state. As compared to other reported photochromic molecules, the system in this study has its advantages of facile synthesis and tunable thermal bleaching rate, and also provides new insights into the development of photochromic materials based on metal complex and spirolactam-containing dyes.

Fluorescent salicylaldehyde hydrazone as selective chemosensor for Zn 2+ in aqueous ethanol: A ratiometric approach

4-N,N-diethylaminosalicylaldehyde hydrazone Schiff base (1) and its analogues (2-6) were synthesized and characterized by NMR, MS and elemental analysis. Compound 1 exhibited ratiometric fluorescent response to Zn 2+ over other metal ions in aqueous ethanol solution with neutral buffer. The complexation ratio, site and constant and the effect of pH value and water fraction on its fluorescent response to Zn2+ were investigated. Copyright