1341200-72-3 Usage
Chemical classification
It is a sulfonyl chloride derivative.
Contains functional groups
It contains a sulfonyl chloride functional group, a pyrimidine, and a benzene ring.
Industrial application
It is commonly used in the pharmaceutical industry for the synthesis of various drugs.
Medical importance
It is important for the development of antiviral and antifungal drugs due to its ability to inhibit the activity of certain enzymes in microorganisms.
Other uses
It is also used in the synthesis of agrochemicals and dyes, and is a key intermediate in organic synthesis and is widely used in the production of various fine chemicals.
Versatility
Its versatile structure and reactivity make it an important building block for the production of various pharmaceutical and chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 1341200-72-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,1,2,0 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1341200-72:
(9*1)+(8*3)+(7*4)+(6*1)+(5*2)+(4*0)+(3*0)+(2*7)+(1*2)=93
93 % 10 = 3
So 1341200-72-3 is a valid CAS Registry Number.
1341200-72-3Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of a series of novel AXL kinase inhibitors
Mollard, Alexis,Warner, Steven L.,Call, Lee T.,Wade, Mark L.,Bearss, Jared J.,Verma, Anupam,Sharma, Sunil,Vankayalapati, Hariprasad,Bearss, David J.
, p. 907 - 912 (2012/01/19)
The receptor tyrosine kinase AXL has emerged in recent years as an potential oncology target due to its overexpression in several types of cancers coupled with its ability to promote tumor growth and metastasis. To identify small molecule inhibitors of AXL, we built a homology model of its catalytic domain to virtually screen and identify scaffolds displaying an affinity for AXL. Further computational and structure-based design resulted in the synthesis of a series of 2,4,5-trisubstitued pyrimidines, which demonstrated potent inhibition of AXL in vitro (IC50 = 19 nM) and strongly inhibited the growth of several pancreatic cell lines.
