1341200-86-9 Usage
General Description
2,5-dichloro-N-(4-fluorophenyl)-N-methylpyrimidin-4-amine is a chemical compound with the molecular formula C12H10Cl2FN3. It is a synthetic organic compound that belongs to the class of pyrimidine derivatives. This chemical is characterized by its dichloro and methyl substituents on the pyrimidine ring, as well as a fluorophenyl group attached to the nitrogen atom. It is often used in various research and industrial applications, including as a building block in the synthesis of pharmaceuticals and agrochemicals. Additionally, it may also have potential biological and pharmacological activities that make it of interest in medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 1341200-86-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,1,2,0 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1341200-86:
(9*1)+(8*3)+(7*4)+(6*1)+(5*2)+(4*0)+(3*0)+(2*8)+(1*6)=99
99 % 10 = 9
So 1341200-86-9 is a valid CAS Registry Number.
1341200-86-9Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of a series of novel AXL kinase inhibitors
Mollard, Alexis,Warner, Steven L.,Call, Lee T.,Wade, Mark L.,Bearss, Jared J.,Verma, Anupam,Sharma, Sunil,Vankayalapati, Hariprasad,Bearss, David J.
supporting information; experimental part, p. 907 - 912 (2012/01/19)
The receptor tyrosine kinase AXL has emerged in recent years as an potential oncology target due to its overexpression in several types of cancers coupled with its ability to promote tumor growth and metastasis. To identify small molecule inhibitors of AXL, we built a homology model of its catalytic domain to virtually screen and identify scaffolds displaying an affinity for AXL. Further computational and structure-based design resulted in the synthesis of a series of 2,4,5-trisubstitued pyrimidines, which demonstrated potent inhibition of AXL in vitro (IC50 = 19 nM) and strongly inhibited the growth of several pancreatic cell lines.
