1341200-89-2 Usage
### Properties
1. Chemical Formula: \textC10\textH5\textCl2\textFN2
2. Structure: A pyrimidine derivative
Description: A type of heterocyclic compound containing a six-membered ring with two nitrogen atoms
3. Use:
Applications: Used as an intermediate in the synthesis of:
Pharmaceuticals
Agrochemicals
Other organic compounds
Properties:
Possesses antimicrobial properties
Studied for potential applications in the development of new drugs
4. Chemical Composition:
Contains:
Two chlorine atoms
One fluorine atom
One phenyl group (C6H5)
### Explanation
As a pyrimidine derivative, it belongs to a class of compounds that have a six-membered heterocyclic ring structure with two nitrogen atoms.
Its use as an intermediate in pharmaceutical, agrochemical, and organic compound synthesis highlights its role in various industries.
The presence of chlorine and fluorine atoms imparts unique properties to the compound, making it valuable for medicinal and agricultural applications.
2,5-dichloro-4-(4-fluorophenyl)pyrimidine's properties and composition contribute to its significance in the fields of medicine, agriculture, and organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1341200-89-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,1,2,0 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1341200-89:
(9*1)+(8*3)+(7*4)+(6*1)+(5*2)+(4*0)+(3*0)+(2*8)+(1*9)=102
102 % 10 = 2
So 1341200-89-2 is a valid CAS Registry Number.
1341200-89-2Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of a series of novel AXL kinase inhibitors
Mollard, Alexis,Warner, Steven L.,Call, Lee T.,Wade, Mark L.,Bearss, Jared J.,Verma, Anupam,Sharma, Sunil,Vankayalapati, Hariprasad,Bearss, David J.
supporting information; experimental part, p. 907 - 912 (2012/01/19)
The receptor tyrosine kinase AXL has emerged in recent years as an potential oncology target due to its overexpression in several types of cancers coupled with its ability to promote tumor growth and metastasis. To identify small molecule inhibitors of AXL, we built a homology model of its catalytic domain to virtually screen and identify scaffolds displaying an affinity for AXL. Further computational and structure-based design resulted in the synthesis of a series of 2,4,5-trisubstitued pyrimidines, which demonstrated potent inhibition of AXL in vitro (IC50 = 19 nM) and strongly inhibited the growth of several pancreatic cell lines.
