1341219-75-7

Upstream product

• 1341219-71-3 N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-O-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide 

Downstream Products

• 1341219-79-1 C₅₄H₅₄N₆O₁₁ 
• 1341219-85-9 C₄₆H₄₆N₆O₉ 

Relevant academic research and scientific papers

Development of the carboxamide protecting group, 4-(tert -butyldimethylsiloxy)-2-methoxybenzyl

The new carboxamide protecting group, 4-(tert-butyldimethylsiloxy)-2- methoxybenzyl (SiMB), has been developed. While this SiMB group can be removed using mild basic desilylation methods, it can also be deprotected under strongly acidic or oxidative conditions. An application of this group to simple carboxamide groups, as well as to more complex and acid-sensitive adenosine derivatives containing a cyclophane scaffold, was also demonstrated.