1341230-63-4Relevant academic research and scientific papers
Synthesis of α-fluoroimines by copper-catalyzed reaction of diarylacetylenes and n-fluorobenzenesulfonimide
Yip, Shu Jan,Yoshidomi, Tetsushi,Murakami, Kei,Itami, Kenichiro
, p. 329 - 331 (2018)
Difunctionalization of unsaturated bonds with fluorinating reagents has been regarded as an efficient route to vicdifunctional organic fluorides. Here we report a coppercatalyzed synthesis of α-fluoroimines from diarylacetylenes and N-fluorobenzenesulfonimide. Mechanistically, the reaction initiates from the generation of imidyl radical, which reacts with alkyne to give the product. The resulting α-fluoroimine can easily be transformed into other organic fluorides such as fluoroketone and fluoroamines.
Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate
Zhou, Jun,Fang, Xiang,Shao, Tongle,Yang, Xueyan,Wu, Fanhong
, p. 54 - 62 (2016/10/05)
A palladium catalyzed Negishi-type α-arylation of α-fluoroketones with electron-rich and electron-deficient aryl halides or phenyl triflate has been developed. This direct mono-α-arylation method generate a variety of ternary α-aryl-α-monofluoroketones easily in good to excellent yields using XPhos as ligand and Cs2CO3as mild base.
Palladium-catalyzed direct α-arylation of α-fluoroketones: A straightforward route to α-fluoro-α-arylketones
Guo, Chen,Wang, Ruo-Wen,Guo, Yong,Qing, Feng-Ling
experimental part, p. 86 - 96 (2012/02/05)
The palladium-catalyzed direct α-arylation of both open-chain and cyclic α-fluoroketones by using P(o-tolyl)3 or RuPhos as ligand and K3PO4·3H2O as mild base has been developed. This method allows a variety of q
EWG assisted nucleophilic fluorination using PPHF: A strategy for the synthesis of 1,2,2-triaryl-2-fluoroethanones
Kumar, Anil,Pal, Anil K.,Anand, Rishi D.,Singh, Tej V.,Venugopalan, Paloth
experimental part, p. 8308 - 8313 (2011/11/12)
The nucleophilic fluorination of 1,2,2-triaryl-2-hydroxyethanones by fluoride ion has been carried out using pyridinium poly(hydrogen fluoride) (PPHF) to give 1,2,2-triaryl-2-fluoroethanones in fairly good yield. The presence of electron withdrawing group
