134154-50-0

Basic information

• Product Name: T-BUTYL-DIMETHYLSILYL-(3-PROPIONYLPHENOL)
• Synonyms: T-BUTYL-DIMETHYLSILYL-(3-PROPIONYLPHENOL);1-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-1-propanone
• CAS NO: 134154-50-0
• Molecular Formula: C₁₅H₂₄O₂Si
• Molecular Weight: 264.44
• Mol File: 134154-50-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 310.7±25.0 °C(Predicted)
• Appearance: /
• Density: 0.945±0.06 g/cm3(Predicted)
• CAS DataBase Reference: T-BUTYL-DIMETHYLSILYL-(3-PROPIONYLPHENOL)(CAS DataBase Reference)
• NIST Chemistry Reference: T-BUTYL-DIMETHYLSILYL-(3-PROPIONYLPHENOL)(134154-50-0)
• EPA Substance Registry System: T-BUTYL-DIMETHYLSILYL-(3-PROPIONYLPHENOL)(134154-50-0)

Safety Data

• Hazardous Substances Data: 134154-50-0(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 100-83-4 meta-hydroxybenzaldehyde 
• 96013-95-5 3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde 
• 179381-04-5 1-[3-(tert-Butyldimethylsilanyloxy)phenyl]propan-1-ol 

Downstream Products

• 476412-44-9 Ethyl (E)-3-[3-(tert-butyldimethylsilanyloxy)-phenyl]pent-2-enoate 
• 909248-20-0 (E)-1-(3-t-butyldimethylsilyloxyphenyl)propan-1-one thiosemicarbazone 
• 134154-16-8 2-{1-[3-(3,4-Difluoro-benzyloxy)-phenyl]-1-methoxy-propyl}-thiazole 
• 129424-08-4 2-<<3-<1-methoxy-1-(thiazol-2-yl)propyl>phenoxy>methyl>naphthalene 
• 129424-15-3 2-{1-[3-(3,4-Dichloro-benzyloxy)-phenyl]-1-methoxy-propyl}-thiazole 
• 129424-13-1 2-{1-Methoxy-1-[3-(naphthalen-1-ylmethoxy)-phenyl]-propyl}-thiazole 
• 134154-18-0 2-{1-Methoxy-1-[3-(3-o-tolyl-prop-2-ynyloxy)-phenyl]-propyl}-thiazole 
• 129424-31-3 2-{1-Methoxy-1-[3-(3-p-tolyl-prop-2-ynyloxy)-phenyl]-propyl}-thiazole 
• 134154-19-1 1-<3-<<3-(3-methylphenyl)prop-2-yn-1-yl>oxy>phenyl>-1-(thiazol-2-yl)propyl methyl ether 
• 129424-10-8 2-[1-methoxy-1-[3-(3-phenylprop-2-ynyloxy)phenyl]propyl]thiazole 
• 129425-11-2 1-<3-(2-phenylethoxy)phenyl>-1-(thiazol-2-yl)propyl methyl ether 
• 134235-16-8 2-{1-Methoxy-1-[3-((E)-3-phenyl-allyloxy)-phenyl]-propyl}-thiazole 
• 131610-00-9 1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>-1-(thiazol-2-yl)propyl methyl ether 
• 131610-04-3 1-<3-(prop-2-yn-1-yloxy)phenyl>-1-(thiazol-2-yl)propyl methyl ether 

Relevant articles and documents

INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF

The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.

Novel vitamin D analogs

Novel vitamin D analogs, markedly active in the fields of cell proliferation and differentiation, are selected from among (4E,6E)-7-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl] phenyl}-3-ethylnona-4, 6-dien-3-ol, (E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phe

Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives

The invention concerns a thiazole of the formula I, STR1 wherein Q1 is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents, or Ar is an optionally substituted 6-membered heterocyclene moiety continuing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl or substituted (1-4C)alkyl or R2 is optionally substituted benzoyl; and Q2 is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I and pharmaceutical compositions containing said thiazole.