134161-23-2

Upstream product

• 135545-23-2 ethyl-(2RS,3E)-5-t-butoxycarbonylamino-2-benzylpent-3-enoate 
• 135560-17-7 ethyl-5-t-butoxycarbonylaminopent-3E-enoate 
• 57042-12-3 5-ethoxycarbonyl-3E-pentenoic acid 
• 142929-56-4 trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide 
• 142929-54-2 ethyl α-<<(tetrahydro-2H-pyran-2-yl)oxy>methyl>benzenepropanoate 
• 108385-58-6 3-Phenyl-2-(tetrahydro-pyran-2-yloxymethyl)-propionaldehyde 
• 107749-65-5 ethyl α-(hydroxymethyl)benzenepropanoate 
• 2021-28-5 ethyl dihydrocinnamate 
• 142929-58-6 1,1-dimethylethyl <4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 142929-55-3 α-ethenyl-β-<<(tetrahydro-2H-pyran-2-yl)oxy>methyl>benzenepropanol 
• 142929-53-1 ethyl α-<(phenylmethoxy)methyl>benzenepropanoate 
• 142929-57-5 4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenamine 

Downstream Products

• 142929-42-8 methyl 13α-<<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>amino>-3,3,14,14-tetramethyl-6,12-dioxo-7-(phenylmethyl)-1,2-dithia-5,11-diazacyclotetradec-8-ene-(4R)-4α-carboxylate hydrochloride 
• 142929-59-7 methyl 13α-<<(1,1-dimethylethoxy)carbonyl>amino>-3,3-14,14-tetramethyl-6,12-dioxo-7-(phenylmethyl)-1,2-dithia-5,11-diazacyclotetradec-8-ene-(4R)-4α-carboxylate 

Relevant academic research and scientific papers

Analogs of the δ opioid receptor selective cyclic peptide [2-D- penicillamine,5-D-penicillamine]-enkephalin: 2',6'-Dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions

In order to develop systemically-active opioid peptides, the δ-selective, opioid pentapeptide [D-Pen2,D-Pen5]-enkephalin (DPDPE) was modified by esterification and by substitution of 2',6'-dimethyltyrosine for tyrosine to yield 4. Co

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF BRADYKININ ANALOGUES WITH Ψ(E,CH=CH) AND Ψ(CH2-NH) ISOSTERIC PEPTIDE BOND REPLACEMENTS

The synthesis of bradykinin analogues is described in which the Gly4-Phe5, Phe5-Ser6 or the Pro7-Phe8 peptide bond has been replaced by a trans carbon-carbon double bond or by a "reduced" peptide bond.Some of the analogues display high potency and prolonged activity in the rat blood pressure test, indicating increased metabolic stability.A clear selectivity is obtained towards the myotropic effect in the guinea pig ileum.