134168-89-1

Basic information

• Product Name: Thiourea, N-(3,5-dichlorophenyl)-N'-(1,2,2-trimethylpropyl)-
• CAS NO: 134168-89-1
• Molecular Formula: C13H18Cl2N2S
• Molecular Weight: 305.271
• Mol File: 134168-89-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thiourea, N-(3,5-dichlorophenyl)-N'-(1,2,2-trimethylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-(3,5-dichlorophenyl)-N'-(1,2,2-trimethylpropyl)-(134168-89-1)
• EPA Substance Registry System: Thiourea, N-(3,5-dichlorophenyl)-N'-(1,2,2-trimethylpropyl)-(134168-89-1)

Safety Data

• Hazardous Substances Data: 134168-89-1(Hazardous Substances Data)

Upstream product

• 3850-30-4 2,2-dimethyl-1-methylpropylamine 
• 6590-93-8 3,5-dichlorophenylisothiocyanate 
• 626-43-7 3,5-Dichloroaniline 

Downstream Products

• 134169-04-3 N-(3,5-dichlorophenyl)-N'-(1,2,2-trimethylpropyl)carbodiimide 

Relevant articles and documents

Synthesis and structure-activity relationships of novel phenylcyanoguanidine derivatives as potassium channel openers

3,5-Di-substituted phenylcyanoguanidine derivatives with halogen, cyano, and/or nitro groups at the 3- and 5-positions of the benzene ring exhibited very strong smooth muscle relaxation activity in vitro, as compared to pinacidil. Among them, N-(3-chloro-5-cyanophenyl)-N'-cyano-N''-tert- pentylguanidine (5s) showed 27-fold more potent activity than pinacidil, and exhibited a stronger and more lasting antihypertensive effect than pinacidil by oral administration to spontaneously hypertensive rats. We propose a new pharmacophore model in which the essential factors for binding to the potassium channel are an NH and a bulky alkyl group.