13418-77-4

Basic information

• Product Name: 2-AMINO-5-METHOXYPYRIMIDINE
• Synonyms: 2-AMINO-5-METHOXYPYRIMIDINE;5-Methoxy-2-pyrimidinamine;2-Pyrimidinamine, 5-methoxy- (9CI);5-Methoxypyrimidin-2-ylamine
• CAS NO: 13418-77-4
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.12858
• Product Categories: PYRIMIDINE;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Heterocycle-Pyrimidine series
• Mol File: 13418-77-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 86-88°C
• Boiling Point: 313℃
• Flash Point: 143℃
• Appearance: Off-white/Powder
• Density: 1.224
• Vapor Pressure: 0.000506mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• PKA: 3.62±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-AMINO-5-METHOXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-METHOXYPYRIMIDINE(13418-77-4)
• EPA Substance Registry System: 2-AMINO-5-METHOXYPYRIMIDINE(13418-77-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 13418-77-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow to Tan Solid

InChI:InChI=1/C5H7N3O/c1-9-4-2-7-5(6)8-3-4/h2-3H,1H3,(H2,6,7,8)

Upstream product

• 506-93-4 guanidine nitrate 
• 68-12-2 N,N-dimethyl-formamide 
• 24332-20-5 methoxyacetaldehyde dimethylacetal 
• 22536-65-8 2-chloro-5-methoxy-pyrimidine 
• 651-06-9 sulfameter 

Downstream Products

• 1283715-46-7 2-{5-{[4-butyl-1-(5-methoxypyrimidin-2-yl)-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}benzonitrile 
• 3163-35-7 N-{4-[(5-methoxypyrimidin-2-yl)sulfamoyl]phenyl}acetamide 
• 1268155-77-6 5-(4-bromobenzyl)-6-butyl-3-(5-methoxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-one 
• 1057667-16-9 N-(5-methoxypyrimidin-2-yl)hexanamide 
• 143489-43-4 6-methoxy-2-(2-methoxy-4-methylthiophenyl)imidazo<1,2-a>pyrimidine 

Relevant articles and documents

Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR

Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotinergic 5HT3A receptor. (1′S,3′R,4′S)-N-(6-phenylpyrimidin-4-yl)-4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine, a potent and selective α7 nAChR partial agonist, was demonstrated to improve cognition in the mouse novel object recognition (NOR) model of episodic memory.

HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANTIVIRAL DRUGS

The present invention relates to a compound of the following formula (I), or a salt, solvate, tautomer, enantiomer, diastereoisomer or racemic mixture thereof: as well as its use as a drug, notably in the treatment of hepatitis C, its preparation process, and the pharmaceutical compositions containing such a compound.

IMIDAZOL [1,2-A] PYRIDINES AND RELATED COMPOUNDS WITH ACTIVITY AT CANNABINOID CB2 RECEPTORS

Disclosed are compounds of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof; and methods of modulating the activity of a cannabinoid CB2 receptor comprising contacting a compound of Formula (I) or Formula (II) with the cannabinoid CB2 receptor. Said compounds are useful in the treatment of various condition and disorders such as pain, and neurodegenerative disorders.