134209-05-5

Upstream product

• 134209-03-3 3-[3-(4-Formyl-phenoxy)-4-hydroxy-phenyl]-propionic acid methyl ester 
• 134209-02-2 [bis(2,2,2-trifluoroethoxy)phosphoryl]acetic acid (2-trimethylsilyl)ethyl ester 

Downstream Products

• 134209-06-6 (Z)-3-{4-[2-Hydroxy-5-(2-methoxycarbonyl-ethyl)-phenoxy]-phenyl}-acrylic acid 
• 134209-08-8 3-{4-Hydroxy-3-[4-((Z)-3-hydroxy-propenyl)-phenoxy]-phenyl}-propionic acid 
• 134209-07-7 3-{4-Hydroxy-3-[4-((Z)-3-hydroxy-propenyl)-phenoxy]-phenyl}-propionic acid methyl ester 

Relevant academic research and scientific papers

Total Synthesis of Combretastatin D-2: Intramolecular Ullmann Macrocyclization Reaction

The total synthesis of combretastatin D-2, a cytotoxic constituent of Combretum caffrum (Combretaceae), is detailed and is based on the implementation of a key intramolecular Ullmann macrocyclization reaction for formation of the cyclic 15-membered caffra