13421-07-3

Upstream product

• 13421-13-1 4-chloro-2-iodobenzoic acid 
• 108-98-5 thiophenol 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 50-84-0 2,4 dichlorobenzoic acid 

Downstream Products

• 6469-87-0 3-chloro-9H-thioxanthen-9-one 
• 13421-08-4 (4-Chloro-2-phenylsulfanyl-phenyl)-methanol 
• 13421-09-5 4-Chloro-1-chloromethyl-2-phenylsulfanyl-benzene 
• 13421-10-8 (4-Chloro-2-phenylsulfanyl-phenyl)-acetonitrile 
• 13421-11-9 (4-Chloro-2-phenylsulfanyl-phenyl)-acetic acid 
• 56446-83-4 4-Chloro-2-(phenylthio)benzoyl chloride 

Relevant academic research and scientific papers

An expedient route to 3-chlorothioxanthen-9-one-10,10-dioxide and derivation by palladium-catalyzed coupling

Chemistry has been developed that allows for the synthesis of a series of novel tricyclic thioxanthen-9-one-10,10-dioxides. A regioselective synthesis of the novel core substrate 3-chlorothioxanthen-9-one-10,10-dioxide was achieved in 85% yield over three steps without the need for chromatographic purification. Subsequent microwave-assisted coupling methodology afforded the desired novel 3-substituted tricyclic compounds in good to excellent yield. Georg Thieme Verlag Stuttgart.

Aminothioxanthone Derivatives

The present invention refers to 350 to 400 nm range of zero increase/decrease high absorbance of photocurable composition in use can be transporting, a light in an ultraviolet range by the irradiation of electromagnetic waves of fluorescent greater efficiency high efficiency that is capable of emitting light, the aminosilane is fluorescent materials reliability thioxanthone derivative.

Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides

This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and commercially available 3-carboxylic acid thioxanthen-9-one-10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alkaline phosphatase reported replicon system for activity against hepatitis C virus.

AGENTS THAT INHIBIT FLAVIVIRUS REPLICATION AND USES THEREOF

The present invention provides compounds with activity against a variety of flaviviruses, uses thereof, and methods for identifying such compounds.