134221-29-7Relevant academic research and scientific papers
SYNTHESIS OF 2,4-DIAMINO-5-ACETYL(ETHOXYCARBONYL)PYRIMIDINES FROM β-DICARBONYL COMPOUNDS AND DICYANDIAMIDE AND THEIR USE FOR BUILDING A PYRIMIDOPYRIMIDINE SYSTEM
Dorokhov, V. A.,Gordeev, M. F.,Komkov, A. V.,Bogdanov, V. S.
, p. 142 - 147 (1991)
2,4-Diamino-5-acetyl(ethoxycarbonyl)-6-methyl(phenyl)pyrimidines were obtained by the reaction of acetylacetone and β-ketocarboxylic acid esters with dicyandiamide in the presence of Ni(OAc)2.It was shown that annelation of the pyrimidine ring with this compound provides a convenient method for building the pyrimidopyrimidine system.New derivatives of 2-aminopyrimidopyrimidine, 7-amino-3H-pyrimido-pyrimidin-4-one, and 7-amino-1H,3H-pyrimido-pyrimidine-2,4-dione were synthesized.
