1342259-86-2Relevant articles and documents
Highly efficient dynamic kinetic resolution of secondary aromatic alcohols at low temperature using a low-cost sulfonated sepiolite as racemization catalyst
Wu, Jian-Ping,Meng, Xiao,Wang, Liang,Xu, Gang,Yang, Li-Rong
, p. 5129 - 5132 (2014/12/10)
A highly efficient dynamic kinetic resolution system for secondary aromatic alcohol using low-cost sulfonated sepiolite as a racemization catalyst has been developed. The system operates at 25 °C, achieves good eep (>99%) and substrate conversi
Dynamic kinetic resolution of secondary aromatic alcohols with new efficient acyl donors
Xu, Gang,Chen, Yongjun,Wu, Jianping,Cheng, Yongmei,Yang, Lirong
experimental part, p. 1373 - 1378 (2011/11/06)
A new and efficient dynamic kinetic resolution (DKR) process of secondary aromatic alcohols by using long carbon-chain esters as acyl donors has been developed. During the process, the transesterification catalyzed by CD8604 was found to be the main reason for the decrease in enantiomeric excess (ee). Using complex acyl donors, such as 4-chlorophenyl valerate, we could effectively inhibit the resin-catalyzed transesterification, and an excellent ee value (>99%) at high yield (>99%) was achieved. The mechanism for the inhibition of resin-catalyzed transesterification is believed to be the formation of micro-micelles in the pores of CD8604. It is noteworthy that the system can be reused more than 20 times without a loss of yield or ee value.